Our Mission

Tailoring heart failure therapies to the patient

Born out of a passion for physiology and hemodynamics, we believe that every patient is entitled to timely treatments to match their unique physiological needs. PAC Dynamic is dedicated to bringing the patient back to the center of heart failure care.

Our Services

Improving outcomes in heart failure one patient at a time

Hemodynamic and Energetic-Based Precision Medicine

Using computational fluid analysis, applied physiology and artificial intelligence together with the patient’s unique hemometabolic profile, we can model the anticipated response of a patient to medications and support devices. We integrate all of this information to create the Virtual Patient Simulator.

We match the patient to the optimal therapy at the optimal time to improve patient outcomes.

Hemodynamic Optimization for Medical Devices

We provide consulting services to medical device companies with the goal to maximize performance from their pump while minimizing the hemodynamic disruption of the structural integrity and function of the native heart.

Our goal is to design medical technologies that are truly “smart” and adapt to the unique physiologic needs of the patient

Hemodynamic Assessment and Prognostication

Using advanced hemodynamic parameters and the concept of the hemometabolic profile, we can provide a complete physiologic assessment for a given patient and provide important prognostic information to guide care.

Complex patients can be referred for a personalized invasive hemodynamic assessment and consultation at our Physiological Assessment Center (PAC).

Smart VADs and Drug Delivery Systems

Using applied physiology and patient-specific modeling, we can define the cardioenergetic state of a patient.

We are building the next generation smart systems that vary based on the real-time physiologic needs to help promote myocardial recovery and stabilization of cardiogenic shock.

Our Team

Building the Future of Heart Failure Care

Jonathan Grinstein MD

Advanced Heart Failure Cardiologist

Pablo Blanco PhD

Mechanical Engineer

Ryo Torii PhD

Mechanical Engineer

Rohan Goswami MD

Advanced Heart Failure Cardiologist

Hector Garcia-Garcia MD, PhD

Interventional Cardiologist

Christos Bourantas MD, PhD

Interventional Cardiologist

Mark Belkin MD

Advanced Heart Failure Cardiologist

Key Publications

Understanding the SCience

In The News

We’re Moving the Field Forward

Cardiologist-Founded PAC Dynamic Wins $150K for Tool to Personalize Patient Care

July 12, 2024

Managed by the Polsky Center for Entrepreneurship and Innovation, the George Shultz Innovation Fund recently awarded a $150,000 co-investment to PAC Dynamic Inc. and CEO Jonathan Grinstein, MD.

Read more at:

https://polsky.uchicago.edu/2024/07/12/cardiologist-founded-pac-dynamic-wins-150k-for-tool-to-improve-patient-care

PAC Dynamic: Predicting Heart Failure Progression for Precision Care

February 12, 2025

PAC Dynamic is a participant in Cohort 4 of Transform, a data science and AI startup accelerator powered at the University of Chicago’s Polsky Center for Entrepreneurship and Innovation and Innovation in collaboration with the Data Science Institute.

Read more at:

https://polsky.uchicago.edu/2025/02/12/pac-dynamic-predicting-heart-failure-progression-for-precision-care

ACC News Story, Science at THT 2025: New Heart Failure Management Technologies

February 12, 2025

Several innovations in the use of novel technologies to better manage patients with HF were also featured in JACC: Basic to Translational Science.

In a research letter authored by Jonathan Grinstein, MD, FACC, et al., the Virtual Patient Simulator, a clinical decision support tool using patient-specific data from hemodynamic assessment in conjunction with a machine learning model for HF patients to more accurately predict an individual’s HF trajectory, is introduced.

Read more at:

https://www.acc.org/Latest-in-Cardiology/Articles/2025/02/12/18/45/Science-at-THT-2025

5 Q’s Interview with Jonathan Grinstein, CEO of PAC Dynamic

March 6, 2025

The Center for Data Innovation spoke with Jonathan Grinstein, CEO of PAC Dynamic, a Chicago-based company that uses AI to personalize heart failure treatment. Grinstein discussed how PAC Dynamic analyzes heart function through data about blood flow and energy use in the body to help doctors make better decisions and optimize treatments for individual patients. 

Read more at:

https://datainnovation.org/2025/03/5-qs-interview-with-jonathan-grinstein-ceo-of-pac-dynamic

Contact Us

Let’s Talk

Phone

(267) 396-2642

(267) DYNAMIC

Location

Chicago, Illinois, USA, 60622

Email

Social Media

Have additional inquiries? Are you unable to find the answers you seek? We are here to help. Let’s engage in a conversation